Transgene integration into the same chromosome location can produce alleles that express at a predictable level, or alleles that are differentially silenced
نویسندگان
چکیده
منابع مشابه
Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes.
Mismatch-repair (MMR) systems promote eukaryotic genome stability by removing errors introduced during DNA replication and by inhibiting recombination between nonidentical sequences (spellchecker and antirecombination activities, respectively). Following a common mismatch-recognition step effected by MutS-homologous Msh proteins, homologs of the bacterial MutL ATPase (predominantly the Mlh1p-Pm...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2000
ISSN: 0890-9369
DOI: 10.1101/gad.849600